Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation
Identifieur interne : 001A29 ( Main/Exploration ); précédent : 001A28; suivant : 001A30Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation
Auteurs : Jasmine Li [Australie] ; Kristine Hardy [Australie] ; Chan Phetsouphanh [Australie] ; Wen Juan Tu [Australie] ; Elissa L. Sutcliffe [Australie] ; Robert Mccuaig [Australie] ; Christopher R. Sutton [Australie] ; Anjum Zafar [Australie] ; C. Mee Ling Munier [Australie] ; John J. Zaunders [Australie] ; Yin Xu [Australie] ; Angelo Theodoratos [Australie] ; Abel Tan [Australie] ; Pek Siew Lim [Australie] ; Tobias Knaute [Allemagne] ; Antonia Masch [Allemagne] ; Johannes Zerweck [Allemagne] ; Vedran Brezar [France] ; Peter J. Milburn [Australie] ; Jenny Dunn [Australie] ; Marco G. Casarotto [Australie] ; Stephen J. Turner [Australie] ; Nabila Seddiki [France] ; Anthony D. Kelleher [Australie] ; Sudha Rao [Australie]Source :
- Journal of Cell Science [ 0021-9533 ] ; 2016.
Descripteurs français
- KwdFr :
- Cellules Jurkat, Chromatine (métabolisme), Facteur de transcription RelA (métabolisme), Histone (), Histone (métabolisme), Humains, Isoenzymes (métabolisme), Lymphocytes T CD4+ (métabolisme), Mémoire immunologique (génétique), Noyau de la cellule (enzymologie), Phosphorylation, Phosphosérine (métabolisme), Protéine kinase C (métabolisme), Régulation de l'expression des gènes, Séquence d'acides aminés, Transcription génétique, Transduction du signal.
- MESH :
- enzymologie : Noyau de la cellule.
- génétique : Mémoire immunologique.
- métabolisme : Chromatine, Facteur de transcription RelA, Histone, Isoenzymes, Lymphocytes T CD4+, Phosphosérine, Protéine kinase C.
- Cellules Jurkat, Histone, Humains, Phosphorylation, Régulation de l'expression des gènes, Séquence d'acides aminés, Transcription génétique, Transduction du signal.
English descriptors
- KwdEn :
- Amino Acid Sequence, CD4-Positive T-Lymphocytes (metabolism), Cell Nucleus (enzymology), Chromatin (metabolism), Gene Expression Regulation, Histones (chemistry), Histones (metabolism), Humans, Immunologic Memory (genetics), Isoenzymes (metabolism), Jurkat Cells, Phosphorylation, Phosphoserine (metabolism), Protein Kinase C (metabolism), Signal Transduction, Transcription Factor RelA (metabolism), Transcription, Genetic.
- MESH :
- chemical , chemistry : Histones.
- chemical , metabolism : Chromatin, Histones, Isoenzymes, Phosphoserine, Protein Kinase C, Transcription Factor RelA.
- enzymology : Cell Nucleus.
- genetics : Immunologic Memory.
- metabolism : CD4-Positive T-Lymphocytes.
- Amino Acid Sequence, Gene Expression Regulation, Humans, Jurkat Cells, Phosphorylation, Signal Transduction, Transcription, Genetic.
Abstract
Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly understood. By genome-wide ChIP-sequencing
Url:
DOI: 10.1242/jcs.181248
PubMed: 27149922
PubMed Central: 4920249
Affiliations:
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Le document en format XML
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Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Microbiology & Immunology</addr-line>,<institution>The Doherty Institute for Infection and Immunity, University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hardy, Kristine" sort="Hardy, Kristine" uniqKey="Hardy K" first="Kristine" last="Hardy">Kristine Hardy</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Phetsouphanh, Chan" sort="Phetsouphanh, Chan" uniqKey="Phetsouphanh C" first="Chan" last="Phetsouphanh">Chan Phetsouphanh</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>The Kirby Institute, UNSW Australia</institution>,<addr-line>Sydney, New South Wales 2052</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tu, Wen Juan" sort="Tu, Wen Juan" uniqKey="Tu W" first="Wen Juan" last="Tu">Wen Juan Tu</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutcliffe, Elissa L" sort="Sutcliffe, Elissa L" uniqKey="Sutcliffe E" first="Elissa L." last="Sutcliffe">Elissa L. Sutcliffe</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccuaig, Robert" sort="Mccuaig, Robert" uniqKey="Mccuaig R" first="Robert" last="Mccuaig">Robert Mccuaig</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutton, Christopher R" sort="Sutton, Christopher R" uniqKey="Sutton C" first="Christopher R." last="Sutton">Christopher R. Sutton</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zafar, Anjum" sort="Zafar, Anjum" uniqKey="Zafar A" first="Anjum" last="Zafar">Anjum Zafar</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Munier, C Mee Ling" sort="Munier, C Mee Ling" uniqKey="Munier C" first="C. Mee Ling" last="Munier">C. Mee Ling Munier</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>The Kirby Institute, UNSW Australia</institution>,<addr-line>Sydney, New South Wales 2052</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zaunders, John J" sort="Zaunders, John J" uniqKey="Zaunders J" first="John J." last="Zaunders">John J. Zaunders</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>The Kirby Institute, UNSW Australia</institution>,<addr-line>Sydney, New South Wales 2052</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>The Kirby Institute, UNSW Australia</institution>,<addr-line>Sydney, New South Wales 2052</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Theodoratos, Angelo" sort="Theodoratos, Angelo" uniqKey="Theodoratos A" first="Angelo" last="Theodoratos">Angelo Theodoratos</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>,<addr-line>Canberra, Australian Capital Territory 0200</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Abel" sort="Tan, Abel" uniqKey="Tan A" first="Abel" last="Tan">Abel Tan</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Pek Siew" sort="Lim, Pek Siew" uniqKey="Lim P" first="Pek Siew" last="Lim">Pek Siew Lim</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knaute, Tobias" sort="Knaute, Tobias" uniqKey="Knaute T" first="Tobias" last="Knaute">Tobias Knaute</name><affiliation wicri:level="1"><nlm:aff id="af5"><institution>JPT Peptide Technologies Gmbh</institution>,<addr-line>Berlin 12489</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Masch, Antonia" sort="Masch, Antonia" uniqKey="Masch A" first="Antonia" last="Masch">Antonia Masch</name><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Enzymology</addr-line>,<institution>Institute of Biochemistry & Biotechnology, Martin-Luther-University Halle-Wittenberg</institution>,<addr-line>Halle 06108</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zerweck, Johannes" sort="Zerweck, Johannes" uniqKey="Zerweck J" first="Johannes" last="Zerweck">Johannes Zerweck</name><affiliation wicri:level="1"><nlm:aff id="af5"><institution>JPT Peptide Technologies Gmbh</institution>,<addr-line>Berlin 12489</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brezar, Vedran" sort="Brezar, Vedran" uniqKey="Brezar V" first="Vedran" last="Brezar">Vedran Brezar</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est Creteil/Vaccine Research Institute</institution>,<addr-line>Creteil 94010</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milburn, Peter J" sort="Milburn, Peter J" uniqKey="Milburn P" first="Peter J." last="Milburn">Peter J. Milburn</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>,<addr-line>Canberra, Australian Capital Territory 0200</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dunn, Jenny" sort="Dunn, Jenny" uniqKey="Dunn J" first="Jenny" last="Dunn">Jenny Dunn</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casarotto, Marco G" sort="Casarotto, Marco G" uniqKey="Casarotto M" first="Marco G." last="Casarotto">Marco G. Casarotto</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>,<addr-line>Canberra, Australian Capital Territory 0200</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J." last="Turner">Stephen J. Turner</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Microbiology & Immunology</addr-line>,<institution>The Doherty Institute for Infection and Immunity, University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est Creteil/Vaccine Research Institute</institution>,<addr-line>Creteil 94010</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>The Kirby Institute, UNSW Australia</institution>,<addr-line>Sydney, New South Wales 2052</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Sudha" sort="Rao, Sudha" uniqKey="Rao S" first="Sudha" last="Rao">Sudha Rao</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Faculty of Education, Science, Technology & Mathematics</addr-line>,<institution>University of Canberra</institution>,<addr-line>Canberra, Australian Capital Territory 2617</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Cell Science</title><idno type="ISSN">0021-9533</idno><idno type="eISSN">1477-9137</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>CD4-Positive T-Lymphocytes (metabolism)</term><term>Cell Nucleus (enzymology)</term><term>Chromatin (metabolism)</term><term>Gene Expression Regulation</term><term>Histones (chemistry)</term><term>Histones (metabolism)</term><term>Humans</term><term>Immunologic Memory (genetics)</term><term>Isoenzymes (metabolism)</term><term>Jurkat Cells</term><term>Phosphorylation</term><term>Phosphoserine (metabolism)</term><term>Protein Kinase C (metabolism)</term><term>Signal Transduction</term><term>Transcription Factor RelA (metabolism)</term><term>Transcription, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules Jurkat</term><term>Chromatine (métabolisme)</term><term>Facteur de transcription RelA (métabolisme)</term><term>Histone ()</term><term>Histone (métabolisme)</term><term>Humains</term><term>Isoenzymes (métabolisme)</term><term>Lymphocytes T CD4+ (métabolisme)</term><term>Mémoire immunologique (génétique)</term><term>Noyau de la cellule (enzymologie)</term><term>Phosphorylation</term><term>Phosphosérine (métabolisme)</term><term>Protéine kinase C (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Séquence d'acides aminés</term><term>Transcription génétique</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Histones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chromatin</term><term>Histones</term><term>Isoenzymes</term><term>Phosphoserine</term><term>Protein Kinase C</term><term>Transcription Factor RelA</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Noyau de la cellule</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Cell Nucleus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Immunologic Memory</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mémoire immunologique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chromatine</term><term>Facteur de transcription RelA</term><term>Histone</term><term>Isoenzymes</term><term>Lymphocytes T CD4+</term><term>Phosphosérine</term><term>Protéine kinase C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Gene Expression Regulation</term><term>Humans</term><term>Jurkat Cells</term><term>Phosphorylation</term><term>Signal Transduction</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules Jurkat</term><term>Histone</term><term>Humains</term><term>Phosphorylation</term><term>Régulation de l'expression des gènes</term><term>Séquence d'acides aminés</term><term>Transcription génétique</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly understood. By genome-wide ChIP-sequencing <italic>ex vivo</italic> human CD4<sup>+</sup> T cells, here, we show that the signaling enzyme, protein kinase C theta (PKC-θ) directly relays stimulatory signals to chromatin by binding to transcriptional-memory-responsive genes to induce transcriptional activation. Flanked by permissive histone modifications, these PKC-enriched regions are significantly enriched with NF-κB motifs in <italic>ex vivo</italic> bulk and vaccinia-responsive human memory CD4<sup>+</sup> T cells. Within the nucleus, PKC-θ catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-κB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition through Ser32 phosphorylation. Furthermore, using a cytoplasm-restricted PKC-θ mutant, we highlight that chromatin-anchored PKC-θ integrates activating signals at the chromatin template to elicit transcriptional memory responses in human memory T cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abbas, A R" uniqKey="Abbas A">A. R. Abbas</name></author><author><name sortKey="Baldwin, D" uniqKey="Baldwin D">D. Baldwin</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y. Ma</name></author><author><name sortKey="Ouyang, W" uniqKey="Ouyang W">W. Ouyang</name></author><author><name sortKey="Gurney, A" uniqKey="Gurney A">A. Gurney</name></author><author><name sortKey="Martin, F" uniqKey="Martin F">F. Martin</name></author><author><name sortKey="Fong, S" uniqKey="Fong S">S. 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Lawson</name></author><author><name sortKey="Pages, H" uniqKey="Pages H">H. Pagès</name></author><author><name sortKey="Lin, S M" uniqKey="Lin S">S. M. Lin</name></author><author><name sortKey="Lapointe, D S" uniqKey="Lapointe D">D. S. Lapointe</name></author><author><name sortKey="Green, M R" uniqKey="Green M">M. R. Green</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Li, Jasmine" sort="Li, Jasmine" uniqKey="Li J" first="Jasmine" last="Li">Jasmine Li</name></noRegion><name sortKey="Casarotto, Marco G" sort="Casarotto, Marco G" uniqKey="Casarotto M" first="Marco G." last="Casarotto">Marco G. Casarotto</name><name sortKey="Dunn, Jenny" sort="Dunn, Jenny" uniqKey="Dunn J" first="Jenny" last="Dunn">Jenny Dunn</name><name sortKey="Hardy, Kristine" sort="Hardy, Kristine" uniqKey="Hardy K" first="Kristine" last="Hardy">Kristine Hardy</name><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><name sortKey="Li, Jasmine" sort="Li, Jasmine" uniqKey="Li J" first="Jasmine" last="Li">Jasmine Li</name><name sortKey="Lim, Pek Siew" sort="Lim, Pek Siew" uniqKey="Lim P" first="Pek Siew" last="Lim">Pek Siew Lim</name><name sortKey="Mccuaig, Robert" sort="Mccuaig, Robert" uniqKey="Mccuaig R" first="Robert" last="Mccuaig">Robert Mccuaig</name><name sortKey="Milburn, Peter J" sort="Milburn, Peter J" uniqKey="Milburn P" first="Peter J." last="Milburn">Peter J. Milburn</name><name sortKey="Munier, C Mee Ling" sort="Munier, C Mee Ling" uniqKey="Munier C" first="C. Mee Ling" last="Munier">C. Mee Ling Munier</name><name sortKey="Phetsouphanh, Chan" sort="Phetsouphanh, Chan" uniqKey="Phetsouphanh C" first="Chan" last="Phetsouphanh">Chan Phetsouphanh</name><name sortKey="Rao, Sudha" sort="Rao, Sudha" uniqKey="Rao S" first="Sudha" last="Rao">Sudha Rao</name><name sortKey="Sutcliffe, Elissa L" sort="Sutcliffe, Elissa L" uniqKey="Sutcliffe E" first="Elissa L." last="Sutcliffe">Elissa L. Sutcliffe</name><name sortKey="Sutton, Christopher R" sort="Sutton, Christopher R" uniqKey="Sutton C" first="Christopher R." last="Sutton">Christopher R. Sutton</name><name sortKey="Tan, Abel" sort="Tan, Abel" uniqKey="Tan A" first="Abel" last="Tan">Abel Tan</name><name sortKey="Theodoratos, Angelo" sort="Theodoratos, Angelo" uniqKey="Theodoratos A" first="Angelo" last="Theodoratos">Angelo Theodoratos</name><name sortKey="Tu, Wen Juan" sort="Tu, Wen Juan" uniqKey="Tu W" first="Wen Juan" last="Tu">Wen Juan Tu</name><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J." last="Turner">Stephen J. Turner</name><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><name sortKey="Zafar, Anjum" sort="Zafar, Anjum" uniqKey="Zafar A" first="Anjum" last="Zafar">Anjum Zafar</name><name sortKey="Zaunders, John J" sort="Zaunders, John J" uniqKey="Zaunders J" first="John J." last="Zaunders">John J. Zaunders</name></country><country name="Allemagne"><noRegion><name sortKey="Knaute, Tobias" sort="Knaute, Tobias" uniqKey="Knaute T" first="Tobias" last="Knaute">Tobias Knaute</name></noRegion><name sortKey="Masch, Antonia" sort="Masch, Antonia" uniqKey="Masch A" first="Antonia" last="Masch">Antonia Masch</name><name sortKey="Zerweck, Johannes" sort="Zerweck, Johannes" uniqKey="Zerweck J" first="Johannes" last="Zerweck">Johannes Zerweck</name></country><country name="France"><noRegion><name sortKey="Brezar, Vedran" sort="Brezar, Vedran" uniqKey="Brezar V" first="Vedran" last="Brezar">Vedran Brezar</name></noRegion><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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